Researchers at the Fox Chase Cancer Center and University of Hawaii Cancer Center are attempting to study the role of a genetic mutation in individuals, known as BAP1, and the susceptibility to certain cancers. Initial research has shown that those who carry the gene may be a particularly heightened risk of developing both malignant mesothelioma and melanoma of the eye.
Mesothelioma, which is most commonly linked to asbestos and erionite exposure, is an aggressive malignancy affecting the lining of the lungs, chest, and abdominal cavity. The disease has no known cure.
The hope is that the study can determine who may be most at risk for developing malignant mesothelioma, particularly among those who have knowingly been exposed to asbestos or erionite.
“This is the first study to demonstrate that individual genetic makeup can greatly influence susceptibility to mesothelioma,” said study co-director, Joseph Testa, Phd. “People exposed to dangerous levels of asbestos or erionite may benefit from this study” Testa added.
Even as survival rates for mesothelioma are discouraging, patient prognosis is directly linked to early detection of the illness. As the disease’s symptoms can easily be mistake for less serious illness, the malignancy will often go undetected until it advances to its later stages. This study should assist those with known asbestos exposure, and whom possess the BAP1 genetic mutation, in being diligent about symptom recognition, potentially improving their prognosis.
Mesothelioma, which is most commonly linked to asbestos and erionite exposure, is an aggressive malignancy affecting the lining of the lungs, chest, and abdominal cavity. The disease has no known cure.
The hope is that the study can determine who may be most at risk for developing malignant mesothelioma, particularly among those who have knowingly been exposed to asbestos or erionite.
“This is the first study to demonstrate that individual genetic makeup can greatly influence susceptibility to mesothelioma,” said study co-director, Joseph Testa, Phd. “People exposed to dangerous levels of asbestos or erionite may benefit from this study” Testa added.
Even as survival rates for mesothelioma are discouraging, patient prognosis is directly linked to early detection of the illness. As the disease’s symptoms can easily be mistake for less serious illness, the malignancy will often go undetected until it advances to its later stages. This study should assist those with known asbestos exposure, and whom possess the BAP1 genetic mutation, in being diligent about symptom recognition, potentially improving their prognosis.
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